I get the impression that most people don’t put much thought into over the counter medication. Other than the warnings on the bottle about not taking more than a certain number in a certain amount of time, these drugs are considered “safe”. You take them when you have a symptom to relieve, you stop when it goes away. It wasn’t until I started taking prescription medication for my mental illness that I realized how much I take OTC meds for granted.
When I first started taking medication one of my friends looked up as much information on my meds as he could find. One of the things he looked for is other things I could and could not take at the same time. And one of the things on the no-no list was NSAIDs.